TITLE:
Cardiometabolic Phenotype and Arterial Stiffness in HIV-Positive Black African Patients
AUTHORS:
Daniel Lemogoum, William Ngatchou, Philippe Van De Borne, Valérie Ndobo, Marc Leeman, Euloge Yagnigni, Emiline Tiogou, Elisabeth Nga, Charles Kouanfack, Luc Van Bortel, Jean-Paul Degaute, Michel P. Hermans
KEYWORDS:
Metabolic Syndrome; Pulse Wave Velocity; Arterial Stiffness; Human Immunodeficiency Virus Infection; Black Cameroonian Patients
JOURNAL NAME:
Open Journal of Preventive Medicine,
Vol.4 No.4,
April
11,
2014
ABSTRACT: Objective: To test
the hypothesis that Human
Immunodeficiency Virus (HIV) infection
in Black patients is associated with increased cardiometabolic risk factors
that may increase aortic stiffness assessed by pulse wave velocity (PWV). Methods: We matched 96 Cameroonian Controls to 238
(Un) treated HIV-positive patients [HIV] for age. In each participant, aortic PWV (ComplioR), blood
pressures (BP), lipid profile and fasting blood glucose (FPG) were measured. Results: Waist circumference was
lower in HIV than in Controls (both p g·dl-1), and of diabetes (FPG > 125 mg·dl-1) were higher in HIV than in the Controls (50% vs 27%, and 23%
vs 1%, respectively; both p p = 0.02). Fasting triglycerides (TG) and the atherogenic
dyslipidemia ratio [log(TG)/HDL-C]
were higher in HIV than in the Controls (both p p > 0.05). HIV patients exhibited a twice-higher prevalence of MetS
(AHA/NHLBI score 33/5) than that of the Controls (41% vs 21%; p 0.01). Similarly, severity of MetS phenotype was higher in HIV as
compared to the Controls (2.14% vs 1.59%; p p = 0.036). Conclusions: HIV infection is associated with higher prevalence
of MetS and its phenotype in Black African patients that may induce increased
aortic stiffness.