TITLE:
Racecadotril in the Treatment of Acute Diarrhoea in Adults. An Individual Patient Data Based Meta-Analysis
AUTHORS:
Benoît Coffin, Habib Hamza, Jean-Marie Vetel, Philippe Lehert
KEYWORDS:
Acute Diarrhoea, Racecadotril, Meta-Analysis
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.5 No.7,
April
10,
2014
ABSTRACT: Racecadotril is an antidiarrhoeal drug with a
pure intestinal antisecretory mechanism of action. Aim: To assess racecadotril efficacy,
whatever its dose, versus placebo in adult
acute diarrhoea. Methods: Individual Patient Data meta-analysis following multilevel
mixed models testing of the significance of the treatment effect adjusted for baseline
covariates. Diarrhoea duration was the common main criteria. Results: Four randomized
clinical trials (n = 669) were identified with raw data. The clinical global impression
evaluated at baseline by the physician was found to be the essential predictor influencing
the outcome. As compared to placebo, the 100 mg dose, the minimum effective dose,
induced a 80% increase of the recovered patient proportion at anytime (Hazard
Ratio = 1.8 [1.3, 2.5], p i.e. recovery within 3 days (p p .