TITLE:
Uptake of Bile Acid into Calcium-Induced Alginate Gel Beads Containing β-Chitosan Weak Acid Salt
AUTHORS:
Yoshifumi Murata, Kyoko Kofuji, Norihisa Nishida, Ryosei Kamaguchi
KEYWORDS:
β-Chitosan; Bile Acid Adsorption; Alginate Gel Bead; Hyperlipidemia
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.5 No.4,
April
9,
2014
ABSTRACT: Recently,
potential applications for β-chitosan (β-CS)
have been examined. In the present study, calcium-induced alginate gel beads
(Alg-Ca) containing weak acid salts of β-CS
were prepared and examined with regard to their ability to adsorb bile acids in
vitro. More than 70% of taurocholate dissolved in solution was taken up by
Alg-Ca containing 100 mg β-CS, sim. ilar
to the degree of uptake observed with Alg-Ca containing α-CS salt. The adsorption of bile acid was affected
by the absolute amount of β-CS and/or
the acid concentration of the preparation. A secondary bile acid,
taurodeoxycholate, was also adsorbed by Alg-Ca containing weak acid salts of β-CS. Therefore, β-CS might be used to adsorb bile acids within the gastrointestinal
tract in the same manner as an anion-exchange resin, and thus serve as a
complementary means by which to prevent hyperlipidemia.