TITLE:
Anti-Lipidemic Effect of Combined Leaf Extracts of Moringa oleifera and Peristrophe bicalyculata in Alloxan-Induced Diabetic Rats
AUTHORS:
I. A. Iwara, G. O. Igile, I. P. Ogar, O. E. Mboso, U. P. Ujong, E. U. Eyong, P. E. Ebong
KEYWORDS:
Diabetes; Anti-Lipidemia; Cholesterol; Moringa oleifera; Peristrophe bicalyculata; Hypertension
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.5 No.4,
April
9,
2014
ABSTRACT: In
this study, the anti-lipidemic effects of combined extracts of Moringa oleifera and Peristrophe bicalyculata in
allxoan-induced diabetic rats were investigated. Fifty four (54) adult male
albino Wistar rats weighing between 140-180 g were shared into 5 parallel
groups consisting of diabetic (DC) and non-diabetic (NC) groups. Each group
consisted of 6 rats. Groups 2-5 were made diabetic using alloxan (150 mg/kg
b.w in distil H2O). Except for groups 1 and 2, animals were gavaged
at doses of 500 mg/kg b.w for the single dose of extract and 250 mg/kg for the
combine extract treatment. Insulin served as a standard drug and was
administered at 5IU/kg b.w. The control animal groups (NC, DC) received 0.2 ml of
normal saline (placebo) for fourteen (14) consecutive days. Groups treated with
extracts showed a significant (p 0.05) change was observed
in HDL-C level in treated groups when compared to the normal control, diabetic
control and insulin groups, suggesting a potential protection against cardiovascular
diseases (CVDs) by these plants. No reduction in body weight was observed
within the experimental period of 14 days. The results obtained in this study
are in agreement with several other research results with these plants and
claims by ethno-medical practitioners on the use of Moringa oleifera and Peristrophe
bicalyculata in the
treatment of hypertension and related CVDs.