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Shiozawa, Y., Pedersen, E.A., Patel, L.R., Ziegler, A.M., Havens, A.M. and Jung, Y., et al. (2010) GAS6/AXL Axis Regulates Prostate Cancer Invasion, Proliferation, and Survival in the Bone Marrow Niche. Neoplasia, 12, 116-127.

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• TITLE: The Bone Microenvironmental Effect in the Dormancy of Cancer

  AUTHORS: Weiwei Shen, Yujie Niu, Helong Zhang

  KEYWORDS: Bone Marrow, Tumor, Metastasis, Dormancy

  JOURNAL NAME: Journal of Cancer Therapy, Vol.5 No.4, March 31, 2014

  ABSTRACT: Tumors have already threatened human life and health for centuries, especially the recurrent of bone metastases is difficult to cure. Relapse can occur years to decades after resection of primary tumor. This phenomenon is common in many clinical cases and animal experimental studies. The effect of traditional radiotherapy and chemotherapy on relapse is very limited, and the patients’ prognosis is poor. Because the delayed occurrence of metastases, researchers put forward a new concept “dormancy”, including a single dormant tumor cell (growth-arrest) and tumor mass dormancy (equivalence of the proliferation rate and apoptosis rate). It is probable that dormant tumor cells are the resource of relapse and the main reason of chemotherapy resistance. The mechanisms mediated tumor cell dormancy are complex and poorly understood, and bone marrow microenvironment plays an important role in this process. This review focuses on the bone marrow microenvironmental effect in inducing cancer cells to dormancy uncovered by the latest researches.