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Madrigal, J.L., Olivenza, R., Moro, M.A., Lizasoain, I., Lorenzo, R., Rodrigo, J. and Leza, J.C. (2001) Glutathione Depletion, Lipid Peroxidation and Mitochondrial Dysfunction Are Induced by Chronic Stress in Rat Brain. Neuropsychopharmacology, 24, 420-429.

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• TITLE: Stress-Induced Changes in Testosterone Secretion in Male Rats: Role of Oxidative Stress and Modulation by Antioxidants

  AUTHORS: Mona Abdullah Al-Damegh

  KEYWORDS: Stress; Rats; Testosterone; LH; Antioxidants; Enzymes

  JOURNAL NAME: Open Journal of Animal Sciences, Vol.4 No.2, March 31, 2014

  ABSTRACT: Seventy adult male albino rats were randomly allotted into 3 main groups: control group (n = 10), acute stress-exposed group (n = 30) and chronic stress-exposed group (n = 30). Each of the stressed groups was subdivided into 3 equal subgroups (n = 10/subgroup, SG): subgroup 1 animals were exposed to immobilization stress, SG2 animals, were given immobilization stress and supplemented with α-tocopherol (vitamin E), SG3 animals were exposed to immobilization stress and supplemented with ascorbic acid (vitamin C). Immobilization stress exposure was applied once for 6 continuous hours in the acute stressed group and was 6 hours daily for 10 consecutive days in the chronic stressed group. In all vitamin supplemented groups, both vitamin E and C were administered orally mixed with the diet in a similar dose of 500 mg/kg diet. This supplementation started 6 weeks prior to the stress exposure and continued throughout the experimental period. At the end of the last immobilization session, sera were harvested from all animals thereafter, animals were sacrificed and the testes were immediately excised and processed for further biochemical investigations. Serum testosterone and luteinizing hormone levels were measured and the activities of antioxidant enzymes [catalase (CAT) & glutathione-s-transferase (GST)] as well as malondialdehyde (MDA) concentrations were determined in sera and testes. Compared to control, the results revealed that acute and chronic immobilization stress caused significant decrease in levels of serum testosterone and luteinizing hormone (LH). Also, significant reductions (P