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Wang, M.Y., Koyama, K., Shimabukuro, M., Mangelsdorf, D., Newgard, C.B. and Unger, R.H. (1998) Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion. Proceedings of the National Academy of Sciences of the United States of Americ, 95, 11921-11926. doi:10.1073/pnas.95.20.11921

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• TITLE: Early postprandial Insulin secretion: Its relation to Insulin sensitivity

  AUTHORS: Udaya M. Kabadi, Mary Kabadi

  KEYWORDS: Insulin Secretion; Insulin Resistance; Impaired Glucose Tolerance; Type 2 Diabetes Mellitus

  JOURNAL NAME: Journal of Diabetes Mellitus, Vol.1 No.1, February 22, 2011

  ABSTRACT: Background: Lack of first phase insulin secretion during oral glucose tolerance test [OGTT] in Type 2 Diabetes Mellitus (DM) is attributed to glucose toxicity. Alternatively, the role of insulin resistance in impaired insulin release secondary to lack of glucose entry into β cells may be responsible, but is not examined. Aim: The role of insulin sensitivity in 1st phase insulin secretion was assessed. Material and Methods: Plasma glucose (G) and insulin (I) concentrations were determined after an overnight fast (F) and upto 60 minutes during OGTT with glucose 75g in 12 normal (N), 14 with impaired glucose tolerance (IGT) and 41 subjects with Type 2 DM. First phase insulin secretion (Δ Insulin) was determined as a percentage rise from baseline 100x (Peak-Basal)/Basal. Insulin sensitivity was determined as FI x FG (mUxmM/L). Results: FG were normal (7.0 mM/L in Type 2 DM. FI x FG and ? insulin were 35 ± 4 and 389 ± 89% in N; 77 ± 5 and 254 ± 65% in IGT; and 235 ± 19 and 95 ± 15% in Type 2 DM. Significant negative correlations were noted between ? insulin one hand and FI x FG on the other amongst all subjects [p