Article citationsMore>>

Xia, Y., McGuffey, J.E., Bhattacharyya, S., Sellergren, B., Yilmaz, E. and Wang, L. (2005) Analysis of the Tobacco-Specific Nitrosamine 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in Urine by Extraction on a Molecularly Imprinted Polymer Column and Liquid Chromatography/ Atmospheric Pressure Ionization Tandem Mass Spectrometry. Analytical Chemistry, 77, 7639-7645. http://dx.doi.org/10.1021/ac058027u

has been cited by the following article:

• TITLE: A Rapid, Validated RP-HPLC Method for the Determination of Seven Volatile N-Nitrosamines in Meat

  AUTHORS: Mohammad Al-Kaseem, Zaid Al-Assaf, François Karabeet

  KEYWORDS: N-Nitrosamines; Rp-HPLC; Food Safety

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.5 No.3, March 27, 2014

  ABSTRACT: The present work reports a rapid reversed-phase high-performance liquid chromatography (RP-HPLC) method for the determination of seven volatile N-nitrosamines namely N-nitrosodimethylamine (NDMA), N-nitrosomethylethylamine (NMEA), N-nitrosodiethylamine (NDEA), N-nitrosodiproylamine (NDPA), N-nitrosodi butylamine (NDBA), N-nitrosopiperidine (NPIP) and N-nitrosopyrrolidine (NPYR) for monitoring food safety. A strategic experimental approach was implemented for the method development. The desired chromatographic separation was achieved on a Symmetry C18 (4.6 × 150 mm, 5 μm) column using gradient elution. The optimized mobile phase consisted of the 10 mM ammonium hydroxide pH = 8.9 and acetonitrile. The eluted compounds were monitored at 231 nm wavelength using spectrophotometric detector. The developed method separated seven compounds from each other within a run time of 10 min. The method is effective for the determination of presence of these carcinogenic compounds. The average extraction recovery of seven nitrosamines was found 84.5%; the precision of method was found less than 2.7% and accuracy was found between 95%-102.5%. The assay could be applied in food monitoring safety.