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Kono, T., Hata, T., Morita, S., Munemoto, Y., Matsui, T., Kojima, H., Takemoto, H., Fukunaga, M., Nagata, N., Shimada, M., Sakamoto, J. and Mishima, H. (2013) Goshajinkigan Oxaliplatin Neurotoxicity Evaluation (GONE): A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Goshajinkigan to Prevent Oxaliplatin-Induced Neuropathy. Cancer Chemotherapy and Pharmacology, 72, 1283-1290.
http://dx.doi.org/10.1007/s00280-013-2306-7

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• TITLE: Effects of a Traditional Japanese Medicine Goshajinkigan, Tokishigyakukagoshuyushokyoto on the Warm and Cold Sense Threshold and Peripheral Blood Flow

  AUTHORS: Rika Tsukada, Takuji Yamaguchi, Liu Hang, Masako Iseki, Hiroyuki Kobayashi, Eiichi Inada

  KEYWORDS: A Traditional Japanese Medicine; Goshajinkigan; Tokishigyakukagoshuyushokyoto; The Warm and Cold Sense Threshold; Peripheral Blood Flow

  JOURNAL NAME: Health, Vol.6 No.8, March 26, 2014

  ABSTRACT: The purpose of this study was to investigate the effects of a traditional Japanese medicine Goshajinkigan (TJ-107) and Tokishigyakukagoshuyushokyoto (TJ-38) on warm sense threshold, cold sense threshold and the peripheral blood flow. 31 healthy volunteers (control group: 9people, TJ-107 group: 12 people, TJ-38group:10 people) were examined. Drugs administered 2.5 g a dose. Analysis was before and after 1 hour dosage. The warm and cold sense threshold in the thenar of the non-handedness site of these subjects was measured using a thermostimulator (Intercross-200, Intercross Co., Tokyo, Japan). The peripheral blood flow in the finger of the non-handedness site of these subjects was measured using a full-field laser perfusion imager (FLPI, Moor Instruments Ltd., England). Control: The vehicle had no significant effect on the warm sense threshold, cold sense threshold and the peripheral blood flow. TJ-107: The warm sense threshold and cold sense threshold were significantly decreased, and the reaction latency of cold sense was significantly shortening. The peripheral blood flow was significantly increased second and third finger at 115.6%, 119.3%, respectively. TJ-38: The cold sense threshold and the reaction latency of cold sense were significantly increased. The peripheral blood flow was significantly increased second and third finger with 114.3%, 112.8%, respectively. These results suggest that TJ-107 and TJ-38 have effects on the changed warm sense threshold, cold sense threshold and increased peripheral blood flow.