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Clement, D.L., De Buyzere, M.L., De Bacquer, D.A., de Leeuw, P.W., Duprez, D.A., Fagard, R.H., Gheeraert, P.J., Missault, L.H., Braun, J.J., Six, R.O., Van Der Niepen, P. and O’Brien, E. (2003) For the Office Versus Ambulatory Pressure Study Investigators. Prognostic Value of Ambulatory Blood Pressure in Patients with Treated Hypertension. The New England Journal of Medicine, 348, 2407-2415. http://dx.doi.org/10.1056/NEJMoa022273

has been cited by the following article:

• TITLE: Physician’s Awareness of Home Blood Pressure in the Treatment of Hypertensive Patients with Chronic Kidney Disease

  AUTHORS: Naoki Sugano, Satoru Kuriyama, Yoichiro Hara, Koki Takane, Yasuhito Takahashi, Yasuko Suetsugu, Takashi Yokoo

  KEYWORDS: Home Blood Pressure; Chronic Kidney Disease; Guideline for High Blood Pressure; Antihypertensive Agents

  JOURNAL NAME: Open Journal of Nephrology, Vol.4 No.1, March 24, 2014

  ABSTRACT: Aim: The majority of guidelines recommended the significance of home-based blood pressure (home-BP) measurement. The present study explored that to what extent, general practitioners (GPs) were aware of the importance of home-BP in the daily clinical practice. Method: We sent out questionnaires to GPs who had been specialized in nephrology and hypertension. The questions focused on the awareness of home-BP and the selections of antihypertensive agents for refractory hypertension in chronic kidney disease (CKD) patients. Results: 1) The majority (95.9%) of the responding GPs had utilized home-BP in their clinical practice. 2) When prescribing a single agent for hypertensive CKD patients, the majority of GPs (87.3%) chose ARB for the first line drug, and Ca channel blockers (CCB) were the second. 3) As an add-on drug to the pre-treatment with an angiotensin receptor blocker (ARB), the majority preferred CCB (82.7%) to diuretics (21.8%). In addition, a fixed combination formula of antihypertensive medication consisting of ARB plus diuretic was accepted by the majority of GPs (78.7%). 4) To improve morning hypertension in patients treated with two or more drugs, 87.8% of the doctors agreed that additional night-time dosing could be useful. The choices of the agents given at night-time varied, mainly with α1-blockers (40.6%), followed by α-blockers (30.5%) and α-methyldopa (19.8%). Conclusion: The majority of GPs in Japan are aware of the importance of the home-BP-based management of CKD. They mainly chose ARB as a first line drug, and ARB plus CCB as an add-on therapy.