TITLE:
No Correlation between AVPR1A Promoter Polymorphisms and Prepulse Inhibition in Patients with Nocturnal Enuresis
AUTHORS:
Sebastian Schulz-Juergensen, Philipp von Bismarck, René Santer, Paul Eggert
KEYWORDS:
AVPR1A Promoter; Prepulse Inhibition; Nocturnal Enuresis; Correlation
JOURNAL NAME:
Open Journal of Nephrology,
Vol.4 No.1,
March
24,
2014
ABSTRACT: Introduction: A correlation between AVPR1A promoter
polymorphisms and prepulse inhibition (PPI) of startle reflexes has been
described in healthy adults. Many children with nocturnal enuresis (NE) have a
reduced PPI and treatment with desamino arginine vasopressin (dDAVP), a ligand
of the arginine vasopressin receptor 1A (AVPR1A), and both improve clanical symptoms and significantly
increase PPI. Methods: In 17 children
(median 9.1 years, range 6.4-17.3) with NE, promoter repeats within the RS1
and RS3 regions of AVPR1A were quantified and correlated to PPI
(native and age-adjusted). Results: No
direct correlation was found between the number of promoter repeats at RS1 and PPI (correlation coefficient—0.240, p = 0.346) or RS3 and PPI (correlation
coefficient—0.0192, p = 0.936), with no change through
age-adjustment of PPI. The different RS3 length subgroups did not show
differences in PPI, nor did differentiation of NE according to clinical subtype
or treatment response to dDAVP show differences in the number of promoter
repeats. Conclusion: The missing
reproducibility of the correlation between AVPR1A promoter polymorphisms and PPI in a
group with wide range of PPI suggests a more complex interaction. Therefore,
further investigations are needed to analyze this very plausible interaction.
Conditions with a reduced PPI, such as enuresis, schizophrenia or autism, are
particularly interesting for this research.