TITLE:
Hereditary Immunity and the Origin of Atherosclerosis
AUTHORS:
Sergey N. Rumyantsev, Vil K. Gerasimov, Jergy Grzezczuk, Roman A. Aron, Nataly F. Avrova, Irina V. Belyakova, Ludmila V. Bobrakova, Kirill F. Dubrov, Ludmila V. Perkus, Vladimir F. Pospelov, Nina M. Rogacheva, Nikolay P. Shabalov
KEYWORDS:
Epidemic Spread; Heterozygosity; Homozygosity; Immune Mosaicism; Integrative Approach; Plaque Formation
JOURNAL NAME:
Open Journal of Immunology,
Vol.4 No.1,
March
21,
2014
ABSTRACT: This paper tries to present new confirmation for the opinion about the infectious origin of atherosclerosis from the viewpoint of the current knowledge of hereditary immunity. The performed integrative investigation included the reinterpretation of known clinical and epidemiological observations, supported by immunological, molecular ecological, genetic, and genomic discoveries. The revealed body of firstly achieved information is compatible with the concept that infectious agents contribute the clue step to the development of atherosclerosis over its initial stage performed during the triggering of the arterial endothelial wall by the molecular agent of proposed infectious origin.