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Watanabe M., Tomiyama-Miyaji C., Kainuma E., Inoue M., Kuwano Y., Ren H.-W., Shen J.-W. and Abo T. (2008) Role of α-adrenergic stimulus in stress-induced modulation of body temperature, blood glucose and innate immunity. Immunology Letters, 115, 43-49. doi:10.1016/j.imlet.2007.09.010

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• TITLE: Internal environment for growth of cancer cells in mice: hypothermia, anemia and lymphocytopenia

  AUTHORS: Mayumi Watanabe, Hiroaki Matsumoto, Chikako Tomiyama, Kohei Akazawa, Toru Abo

  KEYWORDS: Cancer; Hypothermia; Anemia; Immunosuppression; Glycolysis; Mitochondria

  JOURNAL NAME: Health, Vol.3 No.4, April 29, 2011

  ABSTRACT: The internal environment in tumor-bearing mice was investigated in detail. When EL-4 lymphoma cells (5 × 106 cells/mouse) were intraperitoneally inoculated into C57BL/6 mice, approximately 70% of the mice died by day 24. In this regard, the internal environment was compared between control mice, surviving mice and tumor-bearing mice which died. The most prominent sign was hypothermia (