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Heiden M.G.V., Cantley L.C. and Thompson C.B. (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science, 324, 1029-1033. doi:10.1126/science.1160809

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• TITLE: Internal environment for growth of cancer cells in mice: hypothermia, anemia and lymphocytopenia

  AUTHORS: Mayumi Watanabe, Hiroaki Matsumoto, Chikako Tomiyama, Kohei Akazawa, Toru Abo

  KEYWORDS: Cancer; Hypothermia; Anemia; Immunosuppression; Glycolysis; Mitochondria

  JOURNAL NAME: Health, Vol.3 No.4, April 29, 2011

  ABSTRACT: The internal environment in tumor-bearing mice was investigated in detail. When EL-4 lymphoma cells (5 × 106 cells/mouse) were intraperitoneally inoculated into C57BL/6 mice, approximately 70% of the mice died by day 24. In this regard, the internal environment was compared between control mice, surviving mice and tumor-bearing mice which died. The most prominent sign was hypothermia (