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Watanabe M., Miyajima K., Matsui I., Tomiyama-Miyaji C., Kainuma E., Inoue M., Matsumoto H., Kuwano Y. and Abo T. (2010) Internal environment in cancer patients and proposal that carcinogenesis is adaptive response of glycolysis to overcome adverse internal conditions. Health, 2, 781-788. doi:10.4236/health.2010.27118

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• TITLE: Internal environment for growth of cancer cells in mice: hypothermia, anemia and lymphocytopenia

  AUTHORS: Mayumi Watanabe, Hiroaki Matsumoto, Chikako Tomiyama, Kohei Akazawa, Toru Abo

  KEYWORDS: Cancer; Hypothermia; Anemia; Immunosuppression; Glycolysis; Mitochondria

  JOURNAL NAME: Health, Vol.3 No.4, April 29, 2011

  ABSTRACT: The internal environment in tumor-bearing mice was investigated in detail. When EL-4 lymphoma cells (5 × 106 cells/mouse) were intraperitoneally inoculated into C57BL/6 mice, approximately 70% of the mice died by day 24. In this regard, the internal environment was compared between control mice, surviving mice and tumor-bearing mice which died. The most prominent sign was hypothermia (