TITLE:
Short Report: Association of IL-15 with Peripheral and Hepatic Insulin Sensitivity in Healthy Middle-Aged Men
AUTHORS:
Yuichiro Nishida, Kumpei Tokuyama, Shoichiro Nagasaka, Akira Kiyonaga, Yasuki Higaki, Megumi Hara, Keitaro Tanaka, Hiroaki Tanaka
KEYWORDS:
Inflammatory Cytokine; Interleukin; Adipokine; Insulin Sensitivity
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.4 No.3,
March
21,
2014
ABSTRACT: Rodent study suggests that interleukin
(IL)-15 administration enhances insulin sensitivity. Although it is well known
that circulating levels of typical inflammatory markers (C-reactive protein
[CRP] and IL-6) are positively associated with homeostasis model
assessment-insulin resistance (HOMA-IR), there are no studies investigating the
associations of other inflammatory markers including IL-15 with
peripheral/hepatic insulin sensitivity in humans. The current study aimed to
examine the relationship between the levels of adiopokines or inflammatory
cytokines and insulin sensitivity in 8 healthy middle-aged men. Circulating
levels of 10 insulin sensitizing adipokines or inflammatory cytokines (total
adiponectin [APN], high molecular weight adiponectin [HMW-APN], IL-4, IL-5,
IL-6, IL-8, IL-15, interferon [IFN]-γ,
tumor necrosis factor [TNF]-α, and
TNF-β) were measured. A
stable-labeled frequently sampled intravenous glucose tolerance test was
performed to assess peripheral ()
and hepatic ()
insulin sensitivity estimated by 2-compartment minimal model. The levels of 3
inflammatory cytokines (IL-4, IL-6, and IL-15) were significantly and inversely correlated with either and . The association between IL-15 and either or was significant even after adjusting for age
and percent body fat (p