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Nishida, Y., Tokuyama, K., Nagasaka, S., Higaki, Y., Fujimi, K., Kiyonaga, A., Shindo, M., Kusaka, I., Nakamura, T., Ishikawa, S.E., Saito, T., Nakamura, O., Sato, Y. and Tanaka, H. (2002) SG, SI, and EGP of Exercise-Trained Middle-Aged Men Estimated by a Two-Compartment Labeled Minimal Model. American Journal of Physiology: Endocrinology and Metabolism, 283, E809-E816.

has been cited by the following article:

• TITLE: Short Report: Association of IL-15 with Peripheral and Hepatic Insulin Sensitivity in Healthy Middle-Aged Men

  AUTHORS: Yuichiro Nishida, Kumpei Tokuyama, Shoichiro Nagasaka, Akira Kiyonaga, Yasuki Higaki, Megumi Hara, Keitaro Tanaka, Hiroaki Tanaka

  KEYWORDS: Inflammatory Cytokine; Interleukin; Adipokine; Insulin Sensitivity

  JOURNAL NAME: Open Journal of Endocrine and Metabolic Diseases, Vol.4 No.3, March 21, 2014

  ABSTRACT: Rodent study suggests that interleukin (IL)-15 administration enhances insulin sensitivity. Although it is well known that circulating levels of typical inflammatory markers (C-reactive protein [CRP] and IL-6) are positively associated with homeostasis model assessment-insulin resistance (HOMA-IR), there are no studies investigating the associations of other inflammatory markers including IL-15 with peripheral/hepatic insulin sensitivity in humans. The current study aimed to examine the relationship between the levels of adiopokines or inflammatory cytokines and insulin sensitivity in 8 healthy middle-aged men. Circulating levels of 10 insulin sensitizing adipokines or inflammatory cytokines (total adiponectin [APN], high molecular weight adiponectin [HMW-APN], IL-4, IL-5, IL-6, IL-8, IL-15, interferon [IFN]-γ, tumor necrosis factor [TNF]-α, and TNF-β) were measured. A stable-labeled frequently sampled intravenous glucose tolerance test was performed to assess peripheral () and hepatic () insulin sensitivity estimated by 2-compartment minimal model. The levels of 3 inflammatory cytokines (IL-4, IL-6, and IL-15) were significantly and inversely correlated with either and . The association between IL-15 and either or was significant even after adjusting for age and percent body fat (p