TITLE:
Debulking of Keloid Combined with Intralesional Injection of 5-Flurouracil and Triamcinolone versus Intralesional Injection of 5-Flurouracil and Triamcinolone
AUTHORS:
Khalifa E. Sharquie, Adil A. Noaimi, Mahmood R. Al-Karhi
KEYWORDS:
Keloid; 5-Flurouracil; Triamcinolone Acetonide; Debulking
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.4 No.2,
March
20,
2014
ABSTRACT: Background: A wide range of therapies exist for
keloids. But despite the multiple treatment modalities available, keloids still
remain a significant challenge for both the clinician and the patient.
Objective: To assess the effectiveness and safety of debulking of keloid with intralesional injection of 5-flurouracil and
triamcinolone in comparison to
intralesional injection of 5-flurouracil and triamcinolone alone. Patient and
Methods: This single blinded comparative therapeutic outpatient based study was done at the Department of
Dermatology, Baghdad Teaching Hospital during the period from February 2011 to
February 2013. Twenty-three
patients with 52 lesions were
enrolled in the study and consisted of two groups: Group A (26 lesions): Treated by
intralesional injection of combination of 5-flurouracil and triamcinolone
acetonide and repeated every month; Group
B (26 lesions): Debulking was
carried out first and then injection of combination of 5-flurouracil and
triamcinolone acetonide at time
of operation and then repeated
injection monthly. Evaluation was
performed by scoring system with 5 criteria (redness, elevation, hardness,
itching and tenderness). The response was graded as no response, minimal,
moderate or complete response. Results: Both modalities of treatments showed
significant results in treating keloid, but the intralesional therapy alone was slightly better than debulking
plus intralesional and no systemic adverse effects were noticed in both groups.
Conclusion: Both modalities of
therapy were effective in treatment of keloid, and there was no much difference
between them.