TITLE:
Neonatal Alloimmune Thrombocytopenia Due to Maternal Anti HPA1a Antibodies: Case Report and Management of Subsequent Pregnancy
AUTHORS:
Verónica Serrano-dela Cruz, Alicia Martínez-Varea, María José Núñez-Valera, Antonio Abad-Carrascosa, Vicente Diago, Alfredo Perales-Marín
KEYWORDS:
Fetoneonatal Alloimmune Thrombocytopenia; Anti-HPA1a Antibodies
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.4 No.5,
March
20,
2014
ABSTRACT: Fetoneonatal alloimmune
thrombocytopenia is an infrequent and
severe disease that is
unexpectedly found after an uncomplicated first pregnancy. Affected infants
might show unexplained purpura, intracranial hemorrhage, and/or
gastrointestinal or genitourinary hemorrhage. Nevertheless,
in asymptomatic newborns the thrombocytopenia may be discovered incidentally.
We describe a case report that highlights that the incidental diagnosis of FNAIT
allows both properly managing the newborn, and detecting maternal anti-HPA1a
antibodies in order to prevent the disease in subsequent pregnancies. A
non-invasive treatment based on IVIgG allowed to this patient to prevent FNAIT
in her second pregnancy.