TITLE:
Enantioselective Aldol Reactions and Michael Additions Using Proline Derivatives as Organocatalysts
AUTHORS:
Mathieu Wagner, Yohan Contie, Clotilde Ferroud, Gilbert Revial
KEYWORDS:
Aldol Reactions; Michael Additions; Enantioselective; Organocatalysts; Proline Derivatives
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.4 No.1,
March
18,
2014
ABSTRACT: Six compounds including five proline derivatives have been prepared and tested as chiral organocatalysts for enantioselective aldol reactions and Michael additions. The enantiomeric excesses, which are highly dependent on the molecular structure of catalysts as well as experimental conditions, have reached over 98%.