TITLE:
Binol Based Chirality Conversion Reagents for Underivatized Amino Acids
AUTHORS:
Krishnaswamy Velmurugan, Lijun Tang, Raju Nandhakumar
KEYWORDS:
Binol Based Receptors; Chiral Recognition; Amino Acids; Amino Alcohols; Chiral Inversion; 1H-NMR
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.4 No.1,
March
17,
2014
ABSTRACT: Four binol based pyrrole carboxamide chiral receptors has been synthesized and effectively used as a Chirality Conversion Reagent (CCR) for underivatized amino acids. Three points of interactions take place for the conversion process. They are the reversible imine formation, the internal resonance assisted Hydrogen Bonding (RAHB) and the additional hydrogen bonds between the amino acids and the heterocylic moiety of the pendant groups. The conversion efficiency of all the receptors was found to be comparable with those of the receptors reported earlier.