TITLE:
Role of Topical Application of Growth Factors on Periodontal Repair
AUTHORS:
Athraa Yahya Al-Hijazi, Abdul Karim Abed Ali Al-Mahammadawy
KEYWORDS:
Vascular Endothelial Growth Factor; Periodontium Healing; Transforming Growth Factor
JOURNAL NAME:
Natural Science,
Vol.6 No.5,
March
17,
2014
ABSTRACT: Reconstruction of lost or injured periodontal tissues
in such a way that both the original structures and their function are completely
restored. Restoring of lost periodontal tissues involves a creation of new
attachment, including the formation of a new periodontal ligament with its
fibers inserted in newly formed cementum and alveolar bone. The purpose of this
research is to illustrate the biological actions of topical application of growth
factors TGF-β1, VEGF on periodontal cells
and tissues, which are involved in periodontal regeneration. Fifty-four male Albino rats were subjected for non surgical
operation of distal sides of both lower anterior teeth, right side was considered
as experimental site treated with 1 μm of VEGF, TGF-β1, while left side treated with 1 μm of normal saline as a control one. All the samples
were studied histologically and histometry at three interval periods 3, 7, 14 days postoperatively. The results demonstrated that
the mean value of amount of new bone and the mean of the length of junctional epithelia
is showed to be higher in VEGF group, while the mean of periodontal ligament width
and mean of rate of bone maturation are reported to be higher in combination group. High mean value for the width of cellular cementum
is recorded in TGF group. Conclusion: The present study suggested that growth factors
application in injured periodontium have a role in periodontal healing and VEGF
illustrates to be the most powerful one.