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Lisitsyn, D.M., Razumovskii, S.D., Tishenin, M.A. and Titov, V.N. (2004) Kinetic Parameters of Oxidation of Individual Fatty Acids with Ozone. Bulletin of Experimental Biology and Medicine, 138, 457-459. http://dx.doi.org/10.1007/s10517-005-0069-9

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• TITLE: Membrane Fluidity: About the Origin of Autoimmunity

  AUTHORS: Isolde Riede

  KEYWORDS: Membrane Fluidity; Autoimmunity; Essential Fatty Acids; Cholesterol; Protein Conformation

  JOURNAL NAME: Open Journal of Immunology, Vol.4 No.1, March 14, 2014

  ABSTRACT: Fluidity of cellular membranes is essential for life. Two possibilities are known to keep human membranes fluid: unsaturated fatty acids and cholesterol. Whereas liver cells can synthesize cholesterol, unsaturated fatty acids are essential. Life style in Western civilization leads to deprivation of essential fatty acids, to elevated serum-cholesterol-levels and to autoimmunity. Here the hypothesis is presented, and explains the relationship: deprivation of essential fatty acids lead to imminent quasi-crystallization of the membrane. Serum cholesterol-levels are elevated. Incorporation of cholesterol into membranes enhancing fluidity again, is able to repair the effect. At saturation, repair fails. Quasi-crystallization occurs. Proteins tilt into another conformation. This has not been learned during the “self” recognition process of the immune system during the embryonic phase. Immune system attacks the new conformation as “non-self”, autoimmunity emerges.