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Koufman, J.A. (1991) The Otolaryngologic Manifestations of Gastroesophageal Reflux Disease (GERD): A Clinical Investigation of 225 Patients Using Ambulatory 24-Hour pH Monitoring and an Experimental Investigation of the Role of Acid and Pepsin in the Development of Laryngeal. Laryngoscope, 101, 1-78.

has been cited by the following article:

• TITLE: Laryngopharengeal Reflux in Gastroesophageal Reflux Disease: Does “Silent Laryngopharengeal Reflux” Really Exist?

  AUTHORS: Iman Ramzy, Mohamed El Shazly, Raghda Marzaban, Tamer Elbaz, Mina Safwat, Botros Latif

  KEYWORDS: Gastroesophageal Reflux Disease (GERD); Laryngopharyngeal Reflux (LPR); Reflux Symptoms Index (RSI); Reflux Finding Score (RFS)

  JOURNAL NAME: Open Journal of Gastroenterology, Vol.4 No.3, March 14, 2014

  ABSTRACT: Background: Gastroesophageal reflux disease (GERD) is a disorder resulting from the reversed flow of gastroduodenal contents into the esophagus, and producing different symptoms, while laryngopharyngeal reflux (LPR) is a disorder resulting from the reversed flow of gastric contents into the hypopharynx. The aim of this work is to evaluate LPR in cases of GERD. Methods: The present study was performed on fifty GERD patients diagnosed by gastroscope. LPR was assessed by reflux symptoms score (RSI) and reflux finding score (RFS). Accordingly, patients are classified into: Group I = 25 patients with manifest LPR, and Group II = 25 control patients without LPR symptoms. Results: GERD accounts for 17.4% of attendants of gastroscope unit, where manifest LPR accounts for 29.1% of GERD cases recording mean RSI and RFS 16.48 and 8.44 respectively. Silent LPR accounts for 8% recording mean RFS 7. Conclusion: There is a significant direct proportional relationship between severity of GERD and the RSI and RFS (p = 0.015 and 0.005 respectively).