TITLE:
Investigate Evaluation of Oxidative Stress and Lipid Profile in STZ-Induced Rats Treated with Antioxidant Vitamin
AUTHORS:
Abdella Emam Abdella Baragob, Waleed Hassan AlMalki, Hassan Elsiddig Hassan Farag Alla, Asim Ibrahim, Salwa Khojali Muhammed, Samia Abdella
KEYWORDS:
Investigate; Lipid; Profile; STZ; Oxidative Stress; Vitamin E
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.5 No.3,
March
13,
2014
ABSTRACT: The objective of this study was designed to
investigate, evaluate the effect of vitamin E on streptozotocin (STZ)-induced diabetic rats by
showing significant changes in
blood glucose, water, food intake, lipid profile, serum urea and ceratinine
level, and antioxidant enzyme parameters activity. Streptozotocin (STZ)-induced toxicity was
studied in male Waster rats; each divided into four
groups: G1, GII, GIII, and GIV. Control rats GI, rats treated with vitamin E (GII), STZ-induced diabetic rats (GIII), and STZ-induced diabetic rats
treated with vitamin E (G1V). Moreover, vitamin E reduced (p f amount of total
cholesterol, LDL, VLDL, cholesterol and triacyglycerols, and increased HDL
cholesterol) and increased total amount protein in STZ-induced diabetic rats (GIV).
Vitamin prevented modification in the activity of superoxide dismutase (SOD)
and glutathione peroxidase (GSX-Px) and in the
concentration of the lipid hydroperoxide. Finally the study suggested that
vitamin E improved hyperglycaemia and dyslipidaemia while inhibiting the progression
of oxidative stress in STZ-induced diabetic rats.