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Larzarus, S.S., Boushey, H., Fahy, J., Chinchili, V., Lemanske, R., Sorkness, C., Kraft, M., Fish, J., Peters, S. and Craig, T. (2001) Long-Acting Beta2-Agonist Monotherapy vs Continued Therapy with Inhaled Corticosteroids in Patients with Persistent Asthma: A Randomized Controlled Trial. The Journal of the American Medicine Association, 285, 2583-2593. http://dx.doi.org/10.1001/jama.285.20.2583

has been cited by the following article:

• TITLE: Nutraceutical with Anti-Inflammatory Activity for the Management of Airway Remodeling in Bronchial Asthma: Kalanchoe integra Var. Crenata (Andr.) Cuf Leaf Extract

  AUTHORS: Asiedu-Gyekye Isaac Julius, Awortwe Charles, Nyamekye Effah Samuel, Antwi Daniel Ansong, Seidu Mahmood, Adjei Samuel, Banga N’guessan Benoit Kwame, Amoateng Patrick, Nkansah Edwin

  KEYWORDS: Kalanchoe Integra; Asthma; Bronchoconstriction; Goblet Cells; Perivascular Oedema

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.5 No.3, March 13, 2014

  ABSTRACT: Background: Kalanchoe integra is widely used in folklore medicine as an antiasthmatic agent. Previous studies have shown the ameliorating effect of Kalanchoe integra leaf extract [KILE] on bronchial hyperesponsiveness and inflammation. Further, the stabilizing effect of Kalanchoe sp on mast cell degranulation, suggests that Kalanchoe species are suitable candidates for allergic asthma therapy. This study is designed to investigate the anti-asthmatic potential of KILE and monitor the accompanying histopathological and immunobiochemical changes that occur in an animal model of bronchial asthma using ovalbumin sensitized guinea pigs. Method: Thirty male guinea pigs were divided into five groups of six animals each. Bronchial asthma was simulated in guinea pigs using ovalbumin. Both low dose (300 mg/kg) and high dose extract (900 mg/kg) were administered daily for 42 days. Prednisolone (2.5 mg/kg) was the standard drug used. Results: Guinea pigs in all KILE treated groups maintained the integrity of their airway structures: bronchial folds and walls, alveoli, alveolar ducts and sacs. KILE and prednisolone caused a reduction in immune parameters (p 0.001), extent of bronchoconstriction, bronchial wall thickness and goblet cell accumulation in the sensitized guinea pigs. Conclusion: This study demonstrates the anti-asthmatic potential of KILE during prolonged administration by the oral route.