TITLE:
Resistance to Beta Lactam Antibiotics of Pseudomonas aeruginosa Isolated in Community Infections within HIV Infected Persons in Lomé-Togo
AUTHORS:
Majesté Ihou Wateba, Kanyni Ekoue-Kouvahey, Abago Balaka, Komivi Tsatsu, Ousseni Tidjani
KEYWORDS:
HIV-1; Pseudomonas aeruginosa; Resistance Phenotypes; Beta Lactam Antibiotic
JOURNAL NAME:
World Journal of AIDS,
Vol.4 No.1,
March
12,
2014
ABSTRACT: Objective: Describe
resistance to beta lactam antibiotics of Pseudomonas aeruginosa in community infection
within HIV-1 infected persons. Methods: We have studied prospectively from June
15th to December 31st 2013 inthe Clinic
Hotel-Dieu and NGO VISA of Lomé, adult HIV-1 infected patients under anti
retroviral therapy combining tenofovir, lamivudine and efavirenz for at least
one year. The technique of agar diffusion susceptibility using discs of
Ticarcillin + clavulanic acid is used to study the β-lactamase production. The diagnosis of species was performed by
the chloroform test and the test for sensitivity to kanamycin and colistin. Results:
Thirty five strains of Pseudomonas aeruginosa were obtained. The
T-lymphocytes CD4 mediane was 575 cells/mm3 of blood. Urine
represented 15 cases, skin abscesses 11 cases, externa suppurate otitis 7 cases
and vaginal swab for 2 cases. The phenotypes were: wild phenotypes 23 cases
(65.7%), resistant phenotypes 12 cases. Among resistant phenotypes, 4 were complex
phenotype; 5 were ESBL phenotypes; 2 were hyper productive cephalosporinases
phenotypes and 1 was a specific phenotype with impermeability to imipenem. Conclusion:
The acquisition of resistance of Pseudomonas aeruginosa to beta lactam antibiotics
in community infections among HIV-1 infected person incentives controls and
promotes the rational use of antibiotics.