TITLE:
The Content of Some Types of Cytokines in Women of Reproductive Age with Exacerbation and Remission of Chronic Herpes Infection
AUTHORS:
Olga Obukhovа, Aleksandr Trunov, Olga Gorbenko, Alya Shvayk, Liliya Trunovа
KEYWORDS:
Cytokines; Herpes Infection; Chronic Inflammation; Immune Response
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.5 No.4,
March
12,
2014
ABSTRACT: There were investigated levels of
pro-inflammatory and regulatory cytokines (IL-1b, IL-6 and IFN-g) in women of reproductive age in periods of exacerbation and remission
of chronic infection caused by the herpes simplex virus in purpose to study the
pathogenetic features of the course of HSV infection. It is shown that both the
period of exacerbation, and the period of clinical remission of chronic herpes
infection are characterized by increased production of IFN-g, IL-1b and IL-6. However, only the mean values of IL-1b were significantly different in periods of
exacerbation and remission. Moreover, patients with chronic herpes infection
revealed significant heterogeneity of individual values of measured cytokines (IL-1b, IL-6 and IFN-g), which does not depend on the period of clinical disease.