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Salerno, A.G., Silva, T.R., Amaral, M.E., Alberici, L.C., Bonfleur, M.L., Patrício, P.R., Francesconi, E.P.M.S., Grassi-Kassisse, D.M., Vercesi, A.E., Boschero, A.C. and Oliveira, H.C. (2007) Overexpression of Apolipoprotein CIII Increases and CETP Reverses Diet-Induced Obesity in Transgenic Mice. International Journal of Obesity, 31, 1586-1595. http://dx.doi.org/10.1038/sj.ijo.0803646

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• TITLE: Sex Difference in Lactate Production by Adipocytes from Lean Humans

  AUTHORS: Danilo Roberto X. de O. Crege, Henrique José V. Silveira, Élinton Adami Chaim, José Carlos Pareja, Alain Géloen, Dora Maria Grassi-Kassisse

  KEYWORDS: Adipose Tissue; Glycerol; Humans; Lactate; Lipolysis

  JOURNAL NAME: Open Journal of Endocrine and Metabolic Diseases, Vol.4 No.3, March 11, 2014

  ABSTRACT: Lactate is an anaerobic metabolite produced in the absence of an adequate O2 supply. Although for a long time considered to be a waste product of glycolysis resulting from hypoxia, lactate is, in fact, an important source of glucose and also a gluconeogenic precursor, having a role in metabolic and endocrine signaling. Lactate is produced by adipocytes and muscle cells. Objectives: In this study, we investigated the sex differences in lactate production by adipocytes isolated from lean human visceral adipose tissue. Main Methods: The experiments described were done using adipocytes isolated from adipose tissue of lean men and women. Adipocytes were isolated following Rodbell procedure, with modifications, for posterior analysis of glycerol and lactate production. Results: Morphometric analysis revealed no significant differences in the size of adipocytes from men and women (diameter: men: 172 ± 24 μm vs. women: 160 ± 16 μm, n = 4 and 10, respectively). Basal glycerol production was significantly higher in adipocytes from men compared to women (0.34 ± 0.06 vs. 0.16 ± 0.01 μmol/106 cells/60 min; mean ± SEM, n = 7 and 4, respectively; p