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Terrence, S.F., Nello, C., Nigel, D., David, W., Schummer, M. and Haussler, D. (2000) Support vector machine classification and validation of cancer tissue samples using microarray expression data. Bioinformatics, 16, 906-914.

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• TITLE: Diagnosis of long QT syndrome via support vector machines classification

  AUTHORS: Halil Bisgin, Orhan U. Kilinc, Ahmet Ugur, Xiaowei Xu, Volkan Tuzcu

  KEYWORDS: Long QT Syndrome; Discrete Wavelet Transform; Support Vector Machine Classification

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.4 No.4, April 20, 2011

  ABSTRACT: Congenital Long QT Syndrome (LQTS) is a genetic disease and associated with significant arrhythmias and sudden cardiac death. We introduce a noninva-sive procedure in which Discrete Wavelet Trans-form (DWT) is used to extract features from elec-trocardiogram (ECG) time-series data first, then the extracted features data is classified as either abnormal or unaffected using Support Vector Machines (SVM). A total of 26 genetically identified patients with LQTS and 19 healthy controls were studied. Due to the limited number of samples, model selection was done by training 44 instances and testing it on remaining one in each run. The proposed method shows reasonably high average accuracy in LQTS diagnosis when combined with best parameter selection process in the classifica-tion stage. An accuracy of 80%is achieved when Sigmoid kernel is used in v-SVM with parameters v = 0.58 and r = 0.5. The corresponding SVM model showed a classification rate of 21/26 for LQTS pa-tients and 15/19 for controls. Since the diagnosis of LQTS can be challenging, the proposed method is promising and can be a potential tool in the correct diagnosis. The method may be improved further if larger data sets can be obtained and used.