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Saxon, A., Hassner, A., Swabb, E.A., Wheeler, B. and Adkinson Jr., N.F. (1984) Lack of Cross-Reactivity between Aztreonam, a Monobactam Antibiotic, and Penicillin in Penicillin-Allergic Subjects. The Journal of Infectious Diseases, 149, 16-22. http://dx.doi.org/10.1093/infdis/149.1.16

has been cited by the following article:

• TITLE: Aztreonam Cell Mediated Hypersensitivity Cross Reactivity with Beta Lactam Antibiotics: The Possibility That It Exists

  AUTHORS: Ryan Urbas, Raxitkumar Patel, Arka Banerjee

  KEYWORDS: Piperacillin; Aztreonam; Cross; Reactivity; Allergy; Amoxicillin; Drug; Rash; Exanthem; Penicillin; Beta; Lactam; Cephalosporin; IgE; Maculopapular Rash

  JOURNAL NAME: Case Reports in Clinical Medicine, Vol.3 No.3, March 6, 2014

  ABSTRACT: A 61-year-old female with past medical history of maculopapular rash reaction to ciprofloxacin and amoxicillin being treated for diverticulitis develops the same rash with administration of piperacillin/tazobactam and aztreonam. A diffuse maculopapular rash developed after the administration of piperacillin. It resolved with discontinuation of the drug and the patient was switched to aztreonam and a very similar rash developed subsequently. In a review of the literature, there are no documented cases of a patient with an allergy to both aztreonam and piperacillin/tazobactam despite in vivo cross-reactivity. Unfortunately, there are no standardized allergy tests for aztreonam or piperacillin. This case, however, does offer the possibility that aztreonam may not always be the right alternative to persons with beta-lactam antibiotic allergies.