TITLE:
Primary Malignant Lymphoma of Prostate with Silent MYD88 Mutation
AUTHORS:
Keisuke Yoshida, Riko Kitazawa, Munenori Komoda, Chihiro Ito, Ryuma Haraguchi, Sohei Kitazawa
KEYWORDS:
Malignant Lymphoma; Prostate; MYD88
JOURNAL NAME:
Case Reports in Clinical Medicine,
Vol.3 No.3,
March
6,
2014
ABSTRACT: We present a case of primary malignant lymphoma of the
prostate in a 77-year-old Japanese man. Immunohistochemical examinations
revealed the presence of a non-GCB subtype of DLBCL (CD10 (-), Bcl-6 (-), MUM1
(+)), and genetic analysis
disclosed a lack of typical codon 206 or 265 missense mutation in MYD88, suggesting that the case was of
type3 (non-GCB andnon-ABC), a subtype of DLBCL.
Three courses of chemotherapy
(rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and
prednisone (R-CHOP)) were effective, and the patient has been free of the
disease with no local or systemic recurrence for three years. Although the
significance of silent mutation at hot spot
of the highly oncogenic MYD88 gene in
this case is unclear, a minute increase in translational efficiency by
silent mutation may have contributed to the activation of MYD88.