TITLE:
Salivary Duct Carcinoma of the Parotid Gland Definitively Diagnosed by Immunohistochemical Examination of Pulmonary Metastases
AUTHORS:
Mei Yonemoto, Kojiro Onizawa, Kenji Yamagata, Shogo Hasegawa, Toru Yanagawa, Hiroki Bukawa
KEYWORDS:
Salivary Duct Carcinoma (SDC); Immunohistochemistry; Parotid Tumor; Pulmonary Metastases; Autopsy
JOURNAL NAME:
Case Reports in Clinical Medicine,
Vol.3 No.3,
March
6,
2014
ABSTRACT: Salivary duct carcinoma (SDC) is a rare,
high-grade, aggressive malignancy, as having a morphologic resemblance to ductal carcinoma of the
breast. We present here an atypical SDC of the parotid gland in a 63-year-old man that was
diagnosed from immunohistochemical findings. The immunohistochemistry was similar in the parotid
lesion and pulmonary metastases in autopsy specimens, but only the latter showed a
cribriform pattern and comedolike necrosis. Although the parotid tumor was
treated with concurrent chemoradiotherapy and adjuvant chemotherapy for over 21
months, the patient died of respiratory failure caused by advanced pulmonary
metastases.