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Willcox, B.J., Donlon, T.A., He, Q., Chen, R., Grove, J.S., Yano, K., Masaki, K.H., Willcox, D.C., Rodriguez, B. and Curb, J.D. (2008) FOXO3A Genotype Is Strongly Associated with Human Longevity. Proceedings of the National Academy of Sciences of the United States of America, 105, 13987-13992.

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• TITLE: A Genome Wide Association Study for Longevity in Cattle

  AUTHORS: Gábor Mészáros, Sophie Eaglen, Patrik Waldmann, Johann Sölkner

  KEYWORDS: Genome Wide Association; Longevity; False Discovery Rate; Population Structure; Cattle

  JOURNAL NAME: Open Journal of Genetics, Vol.4 No.1, March 5, 2014

  ABSTRACT: Longevity is regarded as the most important functional trait in cattle breeding with high economic value yet low heritability. In order to identify genomic regions associated with longevity, a genome wise association study was performed using data from 4887 Fleckvieh bulls and 33,556 SNPs after quality control. Single SNP regression was used for identification of important SNPs including eigenvectors as a means of correction for population structure. SNPs selected with a false discovery rate threshold of 0.05 and with local false discovery rate identified genomic regions associated with longevity which were subsequently cross checked with the National Center for Biotechnology Information (NCBI) database. This, to identify interesting genes in cattle and their homologue forms in other species. The most notable genes were SYT10 located on chromosome 5, ADAMTS3 on chromosome 6, NTRK2 on chromosome 8 and SNTG1 on chromosome 14 of the cattle genome. Several of the genes found have previously been associated with cattle fertility. Poor fertility is an important culling reason and thereby affects longevity in cattle. Several signals were located in regions sparse with described genes, which suggest that there might be several other non-identified genetic pathways for this important trait.