TITLE:
Leiomyoma with Granulomatous Inflammation: Tissue Confirmation of Sarcoidosis
AUTHORS:
Kimi Verilhac, Jaime Arruda, Miriam D. Post
KEYWORDS:
Sarcoidosis; Leiomyoma; Granulomatous Inflammation
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.4 No.4,
March
5,
2014
ABSTRACT: Granulomatous inflammation of the uterus is rare, and sarcoidosis
involving the uterus is even less common. Sarcoidosis is an idiopathic
granulomatous disease that can affect any organ, but most typically involves
the lungs, lymph nodes, spleen, liver, skin, and eye. Although it can be
diagnosed clinically based on a constellation of symptoms, definitive diagnosis
typically requires demonstration of non-infectious non-caseating granulomas on
tissue biopsy. It is a diagnosis of exclusion, and other causes of
granulomatous inflammation must be excluded. We report here a case of
granulomatous inflammation involving a leiomyoma in a patient with a previous
clinical diagnosis of sarcoidosis. This was the patient’s first tissue-based
diagnosis of sarcoidosis and highlighted the importance of adequate sampling of
routine surgical specimens, as they may harbor signs of systemic disease.