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Ilfeld, B.M., Mariano, E.R., Williams, B.A., Woodard, J.N. and Macario, A. (2007) Hospitalization Costs of Total Knee Arthroplasty with a Continuous Femoral Nerve Block Provided only in the Hospital versus on an Ambulatory Basis: A Retrospective, Case-Control, Cost-Minimization Analysis. Regional Anesthesia and Pain Medicine, 32, 46-54.

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• TITLE: The 5 Hallmarks of Biomaterials Success: An Emphasis on Orthopaedics

  AUTHORS: Dustin L. Williams, Brad M. Isaacson

  KEYWORDS: Biomaterials; Orthopaedics; Implant; Bone; Biofilm

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.5 No.4, February 28, 2014

  ABSTRACT: Over the past 200 years, there has been significant advancements in the fields of bioengineering and orthopaedics. Investigators, clinicians and manufactures are learning that the success of implant systems is not limited to a single factor, but a combination of variables that must work in unison to provide stability and high survivorship. Innovations continue to advance these fields and include: biomimetic alterations, three-dimensional, patient-specific reconstructions and novel coatings to mitigate aseptic loosening or other pathologies. However, implant systems continue to fail in clinical practice since they do not adhere to key fundamental principles. Therefore, this article is intended to highlight 5 hallmarks of biomaterials that should be considered during design, surgery, and post-operative rehabilitation.