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Takeuchi, A., Abe, T., Hirose, M., Kamioka, K., Hamada, A. and Ikeda, N. (2004) Interactive simulation system for artificial ventilation on the internet: Virtual ventilator. Journal of Clinical Monitoring and Computing, 18, 353- 363. doi:10.1007/s10877-005-6268-0

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• TITLE: Theoretical modeling of airways pressure waveform for dual-controlled ventilation with physiological pattern and linear respiratory mechanics

  AUTHORS: Francesco Montecchia

  KEYWORDS: mathematical modeling; mechanical ventilation; controlled breathing; pressure and airflow waveforms; respiratory mechanics; tidal and minute volumes

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.4 No.4, April 22, 2011

  ABSTRACT: The present paper describes the theoretical treatment performed for the geometrical optimization of advanced and improved-shape waveforms as airways pressure excitation for controlled breathings in dual-controlled ventilation applied to anaesthetized or severe brain injured patients, the respiratory mechanics of which can be assumed linear. Advanced means insensitive to patient breathing activity as well as to ventilator settings while improved-shape intends in comparison to conventional square waveform for a progressive approaching towards physiological transpulmonary pressure and respiratory airflow waveforms. Such functional features along with the best ventilation control for the specific therapeutic requirements of each patient can be achieved through the implementation of both diagnostic and compensation procedures effectively carried out by the Advance Lung Ventilation System (ALVS) already successfully tested for square waveform as airways pressure excitation. Triangular and trapezoidal waveforms have been considered as airways pressure excitation. The results shows that the latter fits completely the requirements for a physiological pattern of endoalveolar pressure and respiratory airflow waveforms, while the former exhibits a lower physiological behaviour but it is anyhow periodically recommended for performing adequately the powerful diagnostic procedure.