Article citationsMore>>

Nelson, M.R., Wegmann, D., Ehm, G.M., Kessner, D., St Jean, P., Verzilli, C., Shen, J., Tang, Z., Bacanu, S., Fraser, D., Warren, L., Aponte, J., Liu, X., Zhang, H., Zhang, Y., Li, Y., Li, L., Woollard, P., Topp, S., Hall, M., Nangle, K., Wang, J., Abecasis, G., Cardon, L., Zöllner, S., Whittaker, J., Chissoe, S., Novembre, J. and Mooser, V. (2012) An abundance of rare functional variants in 202 drug target genes sequenced in 14002 people. Science, 337, 100-104. www.sciencemag.org

has been cited by the following article:

• TITLE: Women with overweight, mixed hyperlipidemia, intolerance to glucose and diastolic hypertension

  AUTHORS: Ruth-Maria Korth

  KEYWORDS: Combined Telemedical Care; Overweight; Mixed Hyperlipidemia; Intolerance to Glucose; Hypertension; Renal Endothelium; Dyslipidemia; Women’s Health

  JOURNAL NAME: Health, Vol.6 No.5, February 27, 2014

  ABSTRACT: Primarily healthy women who attended a practice of General Medicine were examined and coded data were evaluated using two statistical methods (n = 248, aged 36 ± 14 years). It was found that participants with LDL-related (mixed) hyperlipidemia showed higher blood pressure, a higher proportion of alcohol problems and/or smoking compared to normolipidemic women (p ≤ 0.05). These hyperlipidemic women who reported alcohol problems and/or smoking more often showed proteinuria and/or hematuria, rise of LDL/HDL, critical fasting blood glucose and lower HDL-cholesterol compared to hyperlipidemic women reporting healthy lifestyle (p ≤ 0.05). Likewise, high triglycerides were associated with rise of blood pressure and intolerance to glucose (p ≤ 0.05) and also with elevated total cholesterol. Alcohol-related hypertriglyceridemia overlapped with diastolic hypertension, rise of body weight and urine pathology, lowering of HDL-cholesterol and critical fasting blood glucose. The motivating message was that women with mixed hyperlipidemia and healthy lifestyle had functionally renal endothelium and healthy HDL-related baseline measures. Altogether, LDL-related hyperlipidemia and/or high triglycerides were correlated with diastolic hypertension whereby critical alcohol consumption declined renal endothelium and lowered HDL-cholesterol implicating baseline strategies to neutralize early risk factors.