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B. A. Carneiro-filho, I. P. F. Lima, D. H. Araújo, M. C. Cavalcante, G. H. P. Carvalho, G. A. C. Brito, V. Lima, S. M. Nunes-Monteiro, F. N. Santos, R. A. Ribeiro and A. A. M. Lima, “Intestinal Barrier Function and Secretion in Methotrexate Induced Rat Intestinal Mucositis,” Digestive Diseases and Sciences, Vol. 49, No. 1, 2004, pp. 65-72.
http://dx.doi.org/10.1023/B:DDAS.0000011604.45531.2c

has been cited by the following article:

• TITLE: Protective Effect of Camellia sinensis on Methotrexate-Induced Small Intestinal Mucositis in Mice

  AUTHORS: Samuel Brito de Almeida, Manuel Carlos Serra Azul Monteiro, Ana Valêska Pinto de Lima, Dalgimar Beserra de Menezes, Sandra Maria Nunes Monteiro

  KEYWORDS: Mucositis; Vitamin E; Camellia Sinensis; Morphometry; Mice; Cathechins

  JOURNAL NAME: Food and Nutrition Sciences, Vol.5 No.5, February 26, 2014

  ABSTRACT: Background: Green tea has been used as a daily beverage for several years. Anti-inflammatory effect of tea has also been depicted in different papers. Therefore we had set forward this study to examine the potential anti- inflammatory activity of green tea in small intestine mucositis experimental models. Aims: Evaluation of anti- inflammatory effects of green tea on mice. Materials and Methods: Green tea decoction (20%) was prepared by soaking 20 g of green tea in 100 ml boiled water separately, soaked for 2 minutes and thereafter filtered. In- flammatory activity was induced using methotrexate (2.75 g/kg/24 h sc), and a protecting effect of mucositis con- dition was investigated by vitamin E and Camellia sinensis decoction. Study Design: An experimental study was approved by an Animal Ethical Commitee. Results: Green tea decoction (20%) has shown significant anti-in- flammatory effects (65% and 70%) on methotrexate-induced acute mucositis model. In villous atrophy Green tea decoction (10% and 20%) has shown no protecting action at different intestinal segments. But at intestinal crypt hyperplasia, green tea decoction has shown 65.74%, as compared to mucositis group. An increase of apoptotic bodies were acchieved at MTX group, CS reduced this occurrence. Conclusion: Taken together, our data indi- cate that green tea (20%) has a potential anti-inflammatory compared vitamin E antioxidant action and cor- roborates with the current trend of tea being promoted as “health drink”. However more pharmacological and biochemical assays is necessary to elucidate mechanisms.