TITLE:
The role of polysaccharides in the molecular evolution of biopolymers
AUTHORS:
Aleksander N. Zimnitskii, Sergey A. Bashkatov, Vadym N. Urazbaev, Aleksey V. Chemeris, Renat S. Yamidanov
KEYWORDS:
Molecular Evolution; Aminoacylation; Polysaccharides; Amino Acids; Nucleic Acids; Guantum Chemistry; PCR
JOURNAL NAME:
Natural Science,
Vol.6 No.2,
February
24,
2014
ABSTRACT: The empirical
(biochemical, the PCR method) and
computational (quantum-chemical, PM3) methods have shown the ability
of polysaccharides to catalyze the polymerization of amino acids and
nucleotides within the physiologically acceptable temperature range. The
possibility of nucleotide aminoacylation in the presence of polysaccharides has
been established. The suggestion has been made that abiogenic aminoacylation
of nucleotides by polysaccharides served as the prototype of the original
aminoacylpre-tRNA-synthetase activity and subsequently determined the
formation of the modern mechanism of genetic information transfer via three
biopolymer types—nucleic acids, proteins and polysaccharides.