TITLE:
The angiotension converting enzyme (ACE) gene I/D polymorphism in different ethnic groups of geriatric age living in the Far North
AUTHORS:
Natalya Arkhipova, Elena Popova, Lena Grigorieva
KEYWORDS:
CHD; Geriatric Age; Risk Factors; ACE Gene; Non-Indigenous and Yakut Patients
JOURNAL NAME:
Health,
Vol.6 No.5,
February
24,
2014
ABSTRACT: The study of ACE gene
I/D polymorphism has been carried out in elderly, senile and long-liver
patients with coronary heart disease (CHD) taking into account their
nationality, age and sex. It has been recorded that with the increase of age
there is a decrease in the frequency of the genotype ACE*I/*I and a tendency of
increase in the frequency of the genotype ACE*D/*D. A comparative analysis of genotypes АСЕ*D/*D and АСЕ*D/*I has showed sex
differences in the frequency of homozygous genotype detection. Left ventricular
hypertrophy can be observed significantly
more often among carriers of genotype ACE*I/*I established by
Sokolow-Lyon ECG signs. Association analysis of ACE gene I/D polymorphism has registered significant differences in BMI and blood lipid parameters.