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Nusgens, B.V., Humbert, P., Rougier, A., Colige, A.C., Haftek, M., Lambert, C.A., Richard, A., Creidi, P. and Lapière, C.M. (2001) Topically applied vitamin C enhances the mRNA level of collagens I and III, their processing enzymes and tissue inhibitor of matrix metalloproteinase 1 in the human dermis. Journal of Investigative Dermatology, 116, 853-859. http://dx.doi.org/10.1046/j.0022-202x.2001. 01362.x

has been cited by the following article:

• TITLE: Tolerability and hydrating effects of an anti-aging gynaecological collagen cream in women in menopause

  AUTHORS: Andrea F. D. Di Stefano, Milko M. Radicioni, Andrea Vele, Anna Mancarella Eberhardt, Giorgio Caccia, Francesca Focanti, Enrica Salvatori

  KEYWORDS: Skin Hydration; Vaginal Moisturiser; Skin Viscoelasticity; Corneometer; Cutometer; Perineum

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.4 No.3, February 21, 2014

  ABSTRACT: Background and Aims: A gynaecological cream containing collagen, phytocollagen, hyaluronate and vitamins was investigated in women in menopause. Methods: The cream was daily applied to the vaginal mucosa and the perineal skin as well as to the abdominal skin (healthy skin used as control) for 1 week and then on alternate days for other 2 weeks. Skin hydration and viscoelasticity were measured at baseline and after 8 and 21 days by Corneometer? CM 825 and Cutometer? MPA 850, respectively. The product use comfort and the moisturising of the vaginal mucosa were evaluated by the volunteers through a questionnaire and a visual analogue scale, respectively. Results: The local tolerability was excellent for nearly all of the volunteers (90% - 95%) and according both to dermatologist’s and gynaecologist’s evaluation. Related adverse reactions had a frequency of 15% (10% vulvovaginal burning sensation and 5% vulvovaginal discomfort). The topical hydration increased both in the perineal and the abdominal skin. Hydration increase vs. baseline was more marked on day 8 than on day 21 and was significant in the abdominal skin (p-value