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Cooper, B.C., Ritchie, J.M., Broghammer, C.L., Coffin, J., Sorosky, J.I., Buller, R.E., Hendrix, M.J. and Sood, A.K. (2002) Preoperative serum vascular endothelial growth factor levels: Significance in ovarian cancer. Clinical Cancer Research, 8, 3193-3197.

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• TITLE: Preoperative serum vascular endothelial growth factor correlated to three dimensional power Doppler indices in ovarian masses

  AUTHORS: Maged R. AbouSeeda, Ghada M. Mansour, Sahar S. Ez-Elarab

  KEYWORDS: Ovarian Cancer; Ovarian Mass; Three Dimensional Power Doppler; VEGF; VI; FI; VFI

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.4 No.3, February 21, 2014

  ABSTRACT: Objective: To assess the preoperative serum levels of vascular endothelial growth factor (VEGF) in ovarian masses compared to normal controls and to find a correlation between VEGF and Doppler indices in ovarian masses. Methods: The study was conducted from December 2009 to September 2012 in the oncology and ultrasound units in department of obstetrics and gynecology, Ain Shams University on 150 patients with ovarian masses. During preoperative workup, serum Ca-125 levels and serum VEGF levels were obtained. Ultrasonographic examination included two and three dimensional power Doppler ultrasound (3DPD). Laparotomic approaches were undertaken to obtain the final pathologic results. VEGF was measured in one hundred normal cases as controls. Results: Final ovarian pathology revealed seventy three malignant ovarian masses and seventy seven were benign. Serum Ca-125 levels in malignant cases were higher compared to those in benign cases (p