TITLE:
Cytoprotectivity of the natural honey against the toxic effects of Doxorubicin in mice
AUTHORS:
Madgida A. Ganash, Muhammad I. Mujallid, Ali A. Al-Robai, Ayoub A. Bazzaz
KEYWORDS:
Toxicity; Doxorubicin (DOX); Protectivity; Natural Honey
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.5 No.3,
February
20,
2014
ABSTRACT: The protectivity of the natural honey has been assessed
against the toxicity of Doxorubicin (DOX) in liver tissues of 106 male Albino
mice Mus musculus strain weighing 37 ± 3 gm. The body and liver weights,
morphological behavior changes, liver function and pathological effects on
liver were recorded. Toxicity study of DOX showed that the LD50 and
LD were 20 and 30 mg/Kg, respectively. Intra-peritoneal (i.p.) injection of
DOX induced significant (p ≤ 0.01-0.001) pathological changes in the health, i.e. general weakness, a few
morphological changes associated with bleedings, ulceration of skin, hair loss,
dimorphism of limbs and bosselation. Daily ingestion of natural honey for seven
weeks has led to significant (p ≤ 0.01-0.001) improvement of these symptoms which
appeared as increases in both body and liver weights in comparison with control
animals. The natural honey had enhanced the function of liver in treated
animals with DOX + honey and reduced the pathological effects of DOX on the
above morphological symptoms as well as in the hepatocytes. It is concluded
that the ingestion of natural honey has a protective potency against the toxic
effects of DOX.