TITLE:
Effect of Slice Thickness Reconstruction on Quantitative Vascular Parameters in Perfusion CT
AUTHORS:
Anxo Martínez-de-Alegría, Roberto García-Figueiras, Sandra Baleato-González, María José Rodriguez-Alvarez, Iago Martínez-Souto, Carmen Villalba-Martín
KEYWORDS:
Tomography; Neoplasms; Blood Supply; Diagnostic Imaging
JOURNAL NAME:
Open Journal of Radiology,
Vol.4 No.1,
February
20,
2014
ABSTRACT: Objective: The purpose of this study was to determine
how the slice thickness reconstruction influences quantitative perfusion CT
parameters. Materials and Methods: Eighteen patients with cancer (15 non-small-cell
lung cancer, 2 rectal cancer and 1 renal cancer) were examined prospectively
with multidetector row CT. A 90-second perfusion study was performed after
intravenous bolus injection of contrast material. Blood flow, blood volume,
mean transit time and permeability-surface area product were determined at
three different slice thickness reconstruction (1.25, 2.5 and 5 mms) both in
tumors and in paraspinal muscle. Mean values, limits of agreement between
measurements and within-subject coefficient of correlation were obtained for
these thicknesses. Results: Mean ± standard deviation BF, BV, MTT and PS in
lesions were 118.7 ± 117.9 mL/min/100g tissue, 8.2 ± 8.2 mL/100g tissue, 7.5 ±
5.4 seconds and 10.3 ± 7.2 mL/min/100g tissue respectively at1.25 mmslice thickness;
116.1 ± 115.7 mL/min/100g tissue, 7.8 ± 8.7 mL/100g tissue, 7 ± 4.5 seconds and
10.4 ± 7.5 mL/min/100g tissue at 2.5 mms; and 119.6 ± 115.7 mL/min/100g tissue,
7.8 ± 8.8 mL/100g tissue, 5.4 ± 3.4 seconds and 9.6 ± 7.5 mL/min/100g tissue at
5 mms. Differences between means for different slice thickness where relatively
small in all parameters (