TITLE:
Relationship between expression of Aurka and clinicopathological characteristics in gastric cancer patients
AUTHORS:
Xiulian Xu, Jiangwei Xiao, Shoujiang Wei, Xianyong Xie, Yifan Huang, Xiaobing Tian, Chongshu Wang
KEYWORDS:
Aurka; Clinicopathology; Gastric Cancer; Helicobacter pylori
JOURNAL NAME:
Health,
Vol.6 No.4,
February
19,
2014
ABSTRACT: The aim of the study was to clarify the role of Aurka
in the process of formation and development of gastric cancer. The expression
of Aurka in gastric cancer and corresponding non-cancerous gastric tissues of
52 gastric cancer patients was assessed with the real-time fluorescence
quantitative polymerase chain reaction (RT-PCR) and immunohistochemistry. We
also analyzed the relationship between the expression level and
clinicopathological characteristics. Aurka gene and protein expression in gastric
cancer tissues in both cases were significantly higher than in corresponding
non-cancerous gastric tissues (both P 0.05, respectively).
Furthermore, Aurka gene expression was markedly higher in gastric cancer
tissues of Helicobacter pylori (HP)-positive
patients than negative ones (P