TITLE:
Application of tissue engineering in stem cell therapy
AUTHORS:
Jong Kyu Hong, Sang Mo Kwon
KEYWORDS:
Stem Cell; Cell Behavior; Scaffold; Tissue Engineering; Tissue Regeneration
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.7 No.2,
February
19,
2014
ABSTRACT: Tissue engineering based on stem
cells has gained interest recently as attempts are made to engineer scaffold
environments mimicking the stem cell niche, which contains a reservoir of
multipotent stem cells that can maintain normal tissue or restore unhealthy
cell populations in response to mechanisms of quiescence, self-renewal, and
differentiation of the stem cells. These cell behaviors are governed by soluble
signals that are systemic or presented by local niche cells. In this review,
current and emergent approaches based on stem cells in the field of tissue
engineering are presented for specific applications of human tissues and
organs. The combination of stem cells and tissue engineering opens new
perspectives in tissue regeneration for stem cell therapy because of the
potential to control stem cell behavior with the physical and chemical
characteristics of the engineered scaffold environment.