Article citationsMore>>

J. Vaughan, C. Donaldson, J. Bittencourt, M. H. Perrin, K. Lewis, S. Sutton, R. Can, A. V. Turnbull, D. Lovejoy, C. Rivier, J. Rivier, P. E. Sawchenko and W. Vale, “Urocortin, A Mammalian Neuropeptide Related to Fish Urotensin 1 and to Corticotropin-Releasing Factor,” Nature, Vol. 378, No. 6554, 1995, pp. 287-292.
http://dx.doi.org/10.1038/378287a0

has been cited by the following article:

• TITLE: Exogenous Urocortin 1 Alters the Respiratory Exchange Ratio after Administration into the Lateral Septum

  AUTHORS: Anna I. Fimmel, Lindsey M. Dono, Matthew N. Yee, Paul J. Currie

  KEYWORDS: Energy Substrate Oxidation; Food Intake; Lateral Septum; Respiratory Quotient; Urocortin

  JOURNAL NAME: Journal of Behavioral and Brain Science, Vol.4 No.2, February 18, 2014

  ABSTRACT: Previous reports have suggested that hypothalamic urocortin 1 (Ucn1) exerts inhibitory control on energy metabolism as direct paraventricular nucleus injections dose-dependently decrease the respiratory energy exchange ratio (RER). Other evidence indicates that Ucn1 injections into the lateral septum may alter metabolic function. Consequently, the present study was designed to further characterize the effects of lateral septal Ucn1 signaling on eating and energy metabolism of adult Sprague-Dawley rats. Ucn1 was infused at the onset of the nocturnal cycle at doses of 10 - 100 pmol. In both females and males the peptide elicited a reliable suppression of food intake and significantly lowered RER over a 4 h postinjection period. The decrease in RER is consistent with enhanced lipid oxidation. Overall these findings suggest that, similar to the paraventricular nucleus, the lateral septum is a critical site of action in mediating the effects of Ucn1 on food intake and energy substrate utilization.