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Moseley, M.E., Cohen, Y., Mintorovitch, J., Chileuitt, L., Shimizu, H., Kucharczyk, J., Wendland, M.F., Weinstein, P.R. and Fazekas, F. (1990) Early Detection of Regional Cerebral Ischemia in Cats: Comparison of Diffusionand T2-Weighted MRI and Spectroscopy. Magnetic Resonance in Medicine, 14, 330-346.
http://dx.doi.org/10.1002/mrm.1910140218

has been cited by the following article:

• TITLE: Apparent Diffusion Coefficient Mapping Using a Multi-Shot Spiral MRI Sequence of the Rat Brain

  AUTHORS: Tomokazu Numano, Koji Hyodo, Naotaka Nitta, Junichi Hata, Nobuaki Iwasaki, Kazuhiro Homma

  KEYWORDS: Diffusion Weighted Imaging (DWI); Echo Planner Imaging (EPI); Spiral MRI Sequence; Apparent Diffusion Coefficient (ADC)

  JOURNAL NAME: Open Journal of Radiology, Vol.4 No.1, February 18, 2014

  ABSTRACT: Purpose: Commonly used diffusion weighted (DW) imaging such as DW spin echo (SE) type echo planar imaging (DW-SE-EPI) is known to be a snapshot-like acquisition and to have a relatively high signal-to-noise ratio. Spiral MRI sequence (SPIRAL) has characteristics similar to these of EPI, but it has rarely been used for diffusion-weighted imaging (DWI). In vivo DW-SPIRAL of the rat brain has almost never been reported. Our purpose in this study was to examine the potential of SE-type two-dimensional (2D) multi-shot spiral acquisition MRI for apparent diffusion coefficient (ADC) mapping of the rat brain in vivo. Materials and Methods: We made an SE-type DW-2D-spiral MRI sequence (DW-SPIRAL) which was prepared on a 2.0-T animal-experiment MR scanner. Comparing the phantom experimental result of DW-SPIRAL with the phantom experimental result of DW SE-type echo-planar imaging (DW-SE-EPI) and conventional DW spin echo imaging (DW-SE), we estimated the characteristics of DW-SPIRAL and assessed the clinical application of DW-SPIRAL in an animal experiment on the rat brain. Results: There was not much difference between the calculated water/glycerol phantom diffusion coefficient of DW-SPIRAL and the calculated diffusion coefficient of DW-SE. This result shows that the DW-SPIRAL sequence is appropriate for use in diffusion weighted imaging. There were fewer phantom image distortions and ghosting artifacts with DW-SPIRAL than with DW-SE-EPI, and this tendency was similar in the animal experiment on the rat brain. Conclusion: The DW-SPIRAL sequence had been successfully tested in phantom experiments and rat brain experiments. It has been demonstrated that the DW-SPIRAL sequence is capable of producing in vivo rat brain DWI.