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Wan, Q., Man, H.Y., Liu, F., Braunton, J., Niznik, H.B., Fun, P.S., Brown, G.M. and Wang, Y.T. (1999) Differential modulation of GABAA receptor function by Mel1a and Mel1b receptors. Nature Neuroscience, 2, 401-403.

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• TITLE: Melatonin changes the electrical spontaneous activity of hippocampal rat neurons at different ages

  AUTHORS: Daniel Perez-Torres, Cruz Reyes-Vázquez, Mireya Velázquez-Paniagua, Bertha P rieto-Gómez

  KEYWORDS: Melatonin; Unitary Neuronal Activity; Hippocampus; Rat; Age

  JOURNAL NAME: Advances in Aging Research, Vol.3 No.1, February 17, 2014

  ABSTRACT: Melatonin, the pineal indole is characterized by being a compound that crosses all cell membranes and which has been attributed to several mechanisms of action. Among these it is the ability to reduce free radicals, thereby reducing the potential aging and cell death. Studies in different age Wistar rats have shown that chronic application of melatonin, in the hippocampus, reduces the concentration of free radicals and keeps its architecture. This study showed that melatonin increases the firing rate and favors the presence of bursting activity in animals of different ages. It is suggested that melatonin conserved hippocampal cells in good anatomical and physiological condition probably as a result of the elimination of free radicals.